| 9/3/2022 | Baldwin-Wallace (7-3) | 28 | at | Mt St Joseph | 31 | OAC | ||
| 9/10/2022 | Mt St Joseph | 43 | at | Alfred (2-8) | 37 | at E8 | ||
| 9/17/2022 | Hope (6-4) | 28 | at | Mt St Joseph | 33 | MIAA | ||
| 10/1/2022 | Mt St Joseph | 55 | at | Manchester (1-9,0-7) | 20 | |||
| 10/8/2022 | Defiance (3-7,3-4) | 35 | at | Mt St Joseph | 55 | |||
| 10/15/2022 | Mt St Joseph | 59 | at | Anderson (1-9,1-6) | 3 | |||
| 10/22/2022 | Mt St Joseph | 44 | at | Hanover (5-5,5-2) | 29 | |||
| 10/29/2022 | Bluffton (2-8,2-5) | 21 | at | Mt St Joseph | 70 | |||
| 11/5/2022 | Mt St Joseph | 27 | at | Franklin (4-6,4-3) | 20 | |||
| 11/12/2022 | Rose-Hulman (6-4,6-1) | 31 | at | Mt St Joseph | 40 | |||
| 11/19/2022 | Mt St Joseph | 21 | at | Alma (11-1) | 41 | D3 Championship Round 1 | at MIAA |
| vs Mt St Joseph | vs Other Opponents | Mt St Joseph compared to OOs | |
| Record: | 1-10 | 47-54 | |
| Points Scored: | 26.64 | 26.13 | -0.51 |
| Points Allowed: | 43.45 | 29.31 | 14.14 |
| Margin: | -16.81 | -3.18 | 13.63 |
| Total Points: | 70.09 | 55.44 | 14.65 |