| 9/3/2022 | Oberlin (0-10) | 14 | at | Kalamazoo | 21 | NCA | ||
| 9/10/2022 | Kenyon (3-7) | 21 | at | Kalamazoo | 24 | NCA | ||
| 9/17/2022 | Kalamazoo | 42 | at | Defiance (3-7) | 23 | at HCA | ||
| 9/24/2022 | Kalamazoo | 23 | at | Alfred (2-8) | 31 | at E8 | ||
| 10/1/2022 | Albion (9-1,5-1) | 48 | at | Kalamazoo | 6 | |||
| 10/8/2022 | Kalamazoo | 17 | at | Olivet (5-5,1-5) | 41 | |||
| 10/15/2022 | Kalamazoo | 17 | at | Adrian (6-4,3-3) | 42 | |||
| 10/22/2022 | Alma (11-1,6-0) | 45 | at | Kalamazoo | 21 | |||
| 10/29/2022 | Kalamazoo | 20 | at | Hope (6-4,3-3) | 66 | |||
| 11/12/2022 | Trine (7-3,3-3) | 42 | at | Kalamazoo | 19 |
| vs Kalamazoo | vs Other Opponents | Kalamazoo compared to OOs | |
| Record: | 7-3 | 45-47 | |
| Points Scored: | 37.30 | 27.05 | -10.25 |
| Points Allowed: | 21.00 | 29.41 | -8.41 |
| Margin: | 16.30 | -2.36 | -18.66 |
| Total Points: | 58.30 | 56.46 | 1.84 |