| 9/3/2022 | North Carolina Wesleyan (3-7) | 7 | at | Randolph-Macon | 49 | USASC | ||
| 9/10/2022 | Randolph-Macon | 41 | at | Catholic (6-5) | 7 | at NEWMAC | ||
| 9/17/2022 | Southern Virginia (1-9) | 20 | at | Randolph-Macon | 47 | USASC | ||
| 10/1/2022 | Guilford (2-8,1-6) | 19 | at | Randolph-Macon | 48 | |||
| 10/8/2022 | Randolph-Macon | 55 | at | Averett (3-7,1-6) | 7 | |||
| 10/15/2022 | Bridgewater VA (9-1,6-1) | 7 | at | Randolph-Macon | 44 | |||
| 10/22/2022 | Randolph-Macon | 35 | at | Shenandoah (8-2,5-2) | 21 | |||
| 10/29/2022 | Randolph-Macon | 35 | at | Washington and Lee (5-5,3-4) | 21 | |||
| 11/5/2022 | Ferrum (1-9,1-6) | 10 | at | Randolph-Macon | 52 | |||
| 11/12/2022 | Randolph-Macon | 38 | at | Hampden-Sydney (5-5,4-3) | 17 | |||
| 11/19/2022 | Cortland (9-2) | 28 | at | Randolph-Macon | 35 | D3 Championship Round 1 | E8 | |
| 11/26/2022 | Randolph-Macon | 32 | at | Delaware Valley (12-1) | 39 | D3 Playoffs Round 2 | at MidAC |
| vs Randolph-Macon | vs Other Opponents | Randolph-Macon compared to OOs | |
| Record: | 1-11 | 63-50 | |
| Points Scored: | 16.92 | 26.81 | 9.89 |
| Points Allowed: | 42.58 | 23.16 | 19.42 |
| Margin: | -25.66 | 3.65 | 29.31 |
| Total Points: | 59.50 | 49.97 | 9.53 |