| 9/11/2010 | Thomas More 56 @ Hanover Panthers 12 | |
| 9/18/2010 | Thomas More 36 @ Geneva Golden Tornadoes 20 | † |
| 9/25/2010 | Washington & Jefferson Presidents 21 @ Thomas More 29 | † |
| 10/2/2010 | Thiel Tomcats 3 @ Thomas More 42 | † |
| 10/9/2010 | Thomas More 31 @ Grove City Wolverines 9 | † |
| 10/16/2010 | St Vincent Bearcats 6 @ Thomas More 24 | † |
| 10/23/2010 | Thomas More 48 @ Bethany WV Bison 14 | † |
| 10/30/2010 | Westminster PA Titans 13 @ Thomas More 37 | † |
| 11/6/2010 | Thomas More 14 @ Waynesburg Yellow Jackets 10 | † |
| 11/13/2010 | Mt St Joseph Lions 0 @ Thomas More 33 | |
| 11/20/2010 | Washington and Lee Generals 14 @ Thomas More 42 (D3 Playoffs Round 1) | |
| 11/27/2010 | Thomas More 7 @ Mary Hardin-Baylor Crusaders 69 |