| 9/11/2010 | Waynesburg 35 @ Wilkes Colonels 38 | |
| 9/18/2010 | Waynesburg 34 @ Thiel Tomcats 6 | † |
| 9/25/2010 | Grove City Wolverines 16 @ Waynesburg 42 | † |
| 10/2/2010 | Waynesburg 17 @ Bethany WV Bison 24 | † |
| 10/9/2010 | Waynesburg 55 @ Geneva Golden Tornadoes 42 | † |
| 10/16/2010 | Westminster PA Titans 23 @ Waynesburg 24 | † |
| 10/23/2010 | Frostburg State Bobcats 7 @ Waynesburg 41 | |
| 10/30/2010 | Waynesburg 34 @ St Vincent Bearcats 28 | † |
| 11/6/2010 | Thomas More Saints 14 @ Waynesburg 10 | † |
| 11/13/2010 | Washington & Jefferson Presidents 31 @ Waynesburg 30 | † |