| 9/4/2010 | Allegheny Gators 28 @ Bethany WV 0 | |
| 9/11/2010 | Bethany WV 31 @ King's Monarchs 29 | |
| 9/18/2010 | Bethany WV 21 @ Washington & Jefferson Presidents 59 | † |
| 9/25/2010 | Geneva Golden Tornadoes 37 @ Bethany WV 33 | † |
| 10/2/2010 | Waynesburg Yellow Jackets 17 @ Bethany WV 24 | † |
| 10/9/2010 | Bethany WV 47 @ Westminster PA Titans 39 | † |
| 10/16/2010 | Bethany WV 41 @ Thiel Tomcats 7 | † |
| 10/23/2010 | Thomas More Saints 48 @ Bethany WV 14 | † |
| 11/6/2010 | Bethany WV 7 @ Grove City Wolverines 21 | † |
| 11/13/2010 | St Vincent Bearcats 28 @ Bethany WV 35 | † |