| 9/4/2010 | Wilmington Quakers 7 @ Mt St Joseph 24 | |
| 9/18/2010 | Anderson Ravens 35 @ Mt St Joseph 42 | † |
| 9/25/2010 | Mt St Joseph 31 @ Bluffton Beavers 10 | † |
| 10/2/2010 | Franklin Grizzlies 41 @ Mt St Joseph 10 | † |
| 10/9/2010 | Mt St Joseph 14 @ Defiance Yellow Jackets 22 | † |
| 10/16/2010 | Rose-Hulman Engineers 13 @ Mt St Joseph 7 | † |
| 10/23/2010 | Mt St Joseph 54 @ Earlham Hustlin' Quakers 6 | † |
| 10/30/2010 | Manchester Spartans 13 @ Mt St Joseph 24 | † |
| 11/6/2010 | Mt St Joseph 15 @ Hanover Panthers 25 | † |
| 11/13/2010 | Mt St Joseph 0 @ Thomas More Saints 33 |