| 9/4/2010 | Washington and Lee 7 @ Franklin & Marshall Diplomats 35 | |
| 9/11/2010 | Washington and Lee 48 @ Sewanee Tigers 17 | |
| 9/25/2010 | Averett Cougars 20 @ Washington and Lee 10 | |
| 10/2/2010 | Washington and Lee 55 @ Guilford Quakers 29 | † |
| 10/9/2010 | Emory & Henry Wasps 24 @ Washington and Lee 45 | † |
| 10/16/2010 | Randolph-Macon Yellow Jackets 28 @ Washington and Lee 42 | † |
| 10/23/2010 | Washington and Lee 35 @ Bridgewater VA Eagles 34 | † |
| 10/29/2010 | Washington and Lee 49 @ Catholic Cardinals 14 | † |
| 11/6/2010 | Hampden-Sydney Tigers 27 @ Washington and Lee 38 | † |
| 11/13/2010 | Washington and Lee 45 @ Juniata Eagles 3 | |
| 11/20/2010 | Washington and Lee 14 @ Thomas More Saints 42 (D3 Playoffs Round 1) |