| 9/4/2010 | Marietta Pioneers 28 @ Thiel 7 | |
| 9/11/2010 | Thiel 0 @ Widener Pride 21 | |
| 9/18/2010 | Waynesburg Yellow Jackets 34 @ Thiel 6 | † |
| 9/25/2010 | Thiel 3 @ St Vincent Bearcats 17 | † |
| 10/2/2010 | Thiel 3 @ Thomas More Saints 42 | † |
| 10/16/2010 | Bethany WV Bison 41 @ Thiel 7 | † |
| 10/23/2010 | Thiel 0 @ Westminster PA Titans 35 | † |
| 10/30/2010 | Geneva Golden Tornadoes 34 @ Thiel 20 | † |
| 11/6/2010 | Washington & Jefferson Presidents 47 @ Thiel 14 | † |
| 11/13/2010 | Thiel 21 @ Grove City Wolverines 35 | † |