| 9/4/2010 | Carnegie Mellon Tartans 28 @ Grove City 21 | |
| 9/11/2010 | Grove City 17 @ Lebanon Valley Flying Dutchmen 14 | |
| 9/18/2010 | Grove City 31 @ Westminster PA Titans 16 | † |
| 9/25/2010 | Grove City 16 @ Waynesburg Yellow Jackets 42 | † |
| 10/9/2010 | Thomas More Saints 31 @ Grove City 9 | † |
| 10/16/2010 | Geneva Golden Tornadoes 7 @ Grove City 13 | † |
| 10/23/2010 | Grove City 17 @ St Vincent Bearcats 42 | † |
| 10/30/2010 | Grove City 14 @ Washington & Jefferson Presidents 21 | † |
| 11/6/2010 | Bethany WV Bison 7 @ Grove City 21 | † |
| 11/13/2010 | Thiel Tomcats 21 @ Grove City 35 | † |