| 9/4/2010 | Hanover 28 @ Centre Praying Colonels 27 1OT | |
| 9/11/2010 | Thomas More Saints 56 @ Hanover 12 | |
| 9/18/2010 | Defiance Yellow Jackets 24 @ Hanover 10 | † |
| 9/25/2010 | Rose-Hulman Engineers 31 @ Hanover 52 | † |
| 10/2/2010 | Hanover 28 @ Anderson Ravens 23 | † |
| 10/9/2010 | Earlham Hustlin' Quakers 23 @ Hanover 51 | † |
| 10/23/2010 | Hanover 35 @ Manchester Spartans 25 | † |
| 10/30/2010 | Hanover 27 @ Bluffton Beavers 20 | † |
| 11/6/2010 | Mt St Joseph Lions 15 @ Hanover 25 | † |
| 11/13/2010 | Hanover 25 @ Franklin Grizzlies 48 | † |