| 9/11/2010 | Washington & Jefferson 0 @ Delaware Valley Aggies 27 | |
| 9/18/2010 | Bethany WV Bison 21 @ Washington & Jefferson 59 | † |
| 9/25/2010 | Washington & Jefferson 21 @ Thomas More Saints 29 | † |
| 10/2/2010 | Westminster PA Titans 7 @ Washington & Jefferson 49 | † |
| 10/9/2010 | St Vincent Bearcats 20 @ Washington & Jefferson 31 | † |
| 10/16/2010 | Frostburg State Bobcats 6 @ Washington & Jefferson 21 | |
| 10/23/2010 | Washington & Jefferson 22 @ Geneva Golden Tornadoes 16 | † |
| 10/30/2010 | Grove City Wolverines 14 @ Washington & Jefferson 21 | † |
| 11/6/2010 | Washington & Jefferson 47 @ Thiel Tomcats 14 | † |
| 11/13/2010 | Washington & Jefferson 31 @ Waynesburg Yellow Jackets 30 | † |
| 11/20/2010 | Franklin & Marshall Diplomats 41 @ Washington & Jefferson 56 (ECAC Southwest Bowl) |