| 9/4/2010 | Northwestern State 21 @ Air Force Falcons 65 | |
| 9/11/2010 | Samford Bulldogs 19 @ Northwestern State 7 | |
| 9/18/2010 | Tarleton State Texans 14 @ Northwestern State 17 | |
| 9/25/2010 | Northwestern State 24 @ North Dakota Sioux 49 | |
| 10/2/2010 | McNeese State Cowboys 24 @ Northwestern State 7 | † |
| 10/9/2010 | Northwestern State 24 @ Central Arkansas Bears 19 | † |
| 10/23/2010 | Northwestern State 16 @ Texas State Bobcats 3 | † |
| 10/30/2010 | Sam Houston Bearkats 20 @ Northwestern State 23 1OT | † |
| 11/6/2010 | Northwestern State 35 @ Southeastern Louisiana Lions 16 | † |
| 11/13/2010 | Nicholls State Colonels 37 @ Northwestern State 7 | † |
| 11/20/2010 | Northwestern State 13 @ Stephen F. Austin Lumberjacks 36 | † |