| 9/4/2010 | Texas State 28 @ Houston Cougars 68 | |
| 9/11/2010 | Southern Arkansas Muleriders 17 @ Texas State 31 | |
| 9/18/2010 | Cal Poly Mustangs 12 @ Texas State 21 | |
| 9/25/2010 | Southern Utah Thunderbirds 28 @ Texas State 42 | |
| 10/9/2010 | Texas State 24 @ Southeastern Louisiana Lions 49 | † |
| 10/16/2010 | Nicholls State Colonels 47 @ Texas State 45 | † |
| 10/23/2010 | Northwestern State Demons 16 @ Texas State 3 | † |
| 10/30/2010 | Texas State 27 @ Stephen F. Austin Lumberjacks 24 | † |
| 11/6/2010 | Central Arkansas Bears 49 @ Texas State 17 | † |
| 11/13/2010 | Texas State 6 @ McNeese State Cowboys 36 | † |
| 11/20/2010 | Texas State 29 @ Sam Houston Bearkats 31 | † |