| 9/4/2010 | Tennessee Tech 3 @ Arkansas Razorbacks 44 | |
| 9/11/2010 | Tennessee Tech 7 @ TCU Horned Frogs 62 | |
| 9/16/2010 | Lane Dragons 0 @ Tennessee Tech 43 | |
| 9/25/2010 | Tennessee Tech 21 @ SE Missouri State Redhawks 23 | † |
| 9/30/2010 | Tennessee-Martin Skyhawks 27 @ Tennessee Tech 24 | † |
| 10/9/2010 | Tennessee Tech 34 @ Austin Peay Governers 21 | † |
| 10/16/2010 | Eastern Illinois Panthers 20 @ Tennessee Tech 34 | † |
| 10/23/2010 | Tennessee Tech 21 @ Tennessee State Tigers 10 | † |
| 11/6/2010 | Tennessee Tech 13 @ Murray State Racers 44 | † |
| 11/13/2010 | Eastern Kentucky Colonels 42 @ Tennessee Tech 29 | † |
| 11/20/2010 | Jacksonville State Gamecocks 24 @ Tennessee Tech 35 | † |