| 9/2/2010 | Hampton 0 @ Central Michigan Chippewas 33 | |
| 9/11/2010 | Hampton 31 @ Howard Bison 21 | † |
| 9/18/2010 | North Carolina A&T Aggies 21 @ Hampton 35 | † |
| 9/30/2010 | Hampton 20 @ Delaware State Hornets 14 | † |
| 10/9/2010 | Hampton 27 @ North Carolina Central Eagles 13 | |
| 10/16/2010 | Norfolk State Spartans 6 @ Hampton 7 | † |
| 10/23/2010 | Hampton 7 @ South Carolina State Bulldogs 10 | † |
| 10/30/2010 | Old Dominion Monarchs 28 @ Hampton 14 | |
| 11/6/2010 | Bethune-Cookman Wildcats 23 @ Hampton 18 | † |
| 11/13/2010 | Hampton 12 @ Florida A&M Rattlers 17 | † |
| 11/20/2010 | Hampton 21 @ Morgan State Golden Bears 16 | † |