| 9/4/2010 | Howard 7 @ Holy Cross Crusaders 38 | |
| 9/11/2010 | Hampton Pirates 31 @ Howard 21 | † |
| 9/18/2010 | Florida A&M Rattlers 50 @ Howard 7 | † |
| 9/25/2010 | Howard 3 vs Morgan State Golden Bears 20 (East Rutherford NJ) | † |
| 10/2/2010 | Lincoln PA Lions 14 @ Howard 28 | |
| 10/9/2010 | Howard 14 @ Furman Paladins 56 | |
| 10/23/2010 | Howard 32 @ North Carolina A&T Aggies 52 | † |
| 10/30/2010 | Norfolk State Spartans 10 @ Howard 9 | † |
| 11/6/2010 | Howard 14 @ South Carolina State Bulldogs 54 | † |
| 11/13/2010 | Howard 20 @ Bethune-Cookman Wildcats 35 | † |
| 11/20/2010 | Delaware State Hornets 53 @ Howard 43 | † |