| 9/5/2010 | Southern Jaquars 37 vs Delaware State 27 (Orlando FL) | |
| 9/11/2010 | Florida A&M Rattlers 17 @ Delaware State 14 | † |
| 9/25/2010 | Delaware State 14 @ Coastal Carolina Chanticleers 34 | |
| 9/30/2010 | Hampton Pirates 20 @ Delaware State 14 | † |
| 10/9/2010 | Delaware State 24 @ Bethune-Cookman Wildcats 47 | † |
| 10/16/2010 | North Carolina A&T Aggies 26 @ Delaware State 31 | † |
| 10/23/2010 | Delaware State 24 @ Morgan State Golden Bears 34 | † |
| 10/30/2010 | South Carolina State Bulldogs 38 @ Delaware State 21 | † |
| 11/6/2010 | North Carolina Central Eagles 7 @ Delaware State 29 | |
| 11/13/2010 | Delaware State 21 @ Norfolk State Spartans 31 | † |
| 11/20/2010 | Delaware State 53 @ Howard Bison 43 | † |