| 9/2/2010 | Norfolk State 0 @ Rutgers Scarlet Knights 31 | |
| 9/11/2010 | North Carolina A&T Aggies 14 @ Norfolk State 23 | † |
| 9/18/2010 | Virginia State Trojans 28 @ Norfolk State 51 | |
| 9/25/2010 | Norfolk State 7 @ Bethune-Cookman Wildcats 21 | † |
| 10/9/2010 | Norfolk State 13 @ South Carolina State Bulldogs 34 | † |
| 10/16/2010 | Norfolk State 6 @ Hampton Pirates 7 | † |
| 10/23/2010 | Florida A&M Rattlers 17 @ Norfolk State 13 | † |
| 10/30/2010 | Norfolk State 10 @ Howard Bison 9 | † |
| 11/6/2010 | Morgan State Golden Bears 25 @ Norfolk State 37 | † |
| 11/13/2010 | Delaware State Hornets 21 @ Norfolk State 31 | † |
| 11/20/2010 | Norfolk State 42 @ Savannah State Tigers 6 |