| 9/4/2010 | Memphis 7 @ Mississippi State Bulldogs 49 | |
| 9/11/2010 | Memphis 27 @ East Carolina Pirates 49 | † |
| 9/18/2010 | Middle Tenn State Blue Raiders 17 @ Memphis 24 | |
| 9/25/2010 | Memphis 13 @ UTEP Miners 16 | † |
| 10/2/2010 | Tulsa Golden Hurricane 48 @ Memphis 7 | † |
| 10/9/2010 | Memphis 0 @ Louisville Cardinals 56 | |
| 10/16/2010 | Southern Miss Golden Eagles 41 @ Memphis 19 | † |
| 10/30/2010 | Houston Cougars 56 @ Memphis 17 | † |
| 11/6/2010 | Tennessee Volunteers 50 @ Memphis 14 | |
| 11/13/2010 | Memphis 13 @ Marshall Thundering Herd 28 | † |
| 11/20/2010 | Memphis 15 @ UAB Blazers 31 | † |
| 11/27/2010 | UCF Knights 37 @ Memphis 17 | † |