| 9/2/2010 | Florida Atlantic Owls 32 @ UAB 31 | |
| 9/11/2010 | UAB 7 @ SMU Mustangs 28 | † |
| 9/18/2010 | Troy Trojans 33 @ UAB 34 | |
| 9/25/2010 | UAB 29 @ Tennessee Volunteers 32 2OT | |
| 10/6/2010 | UAB 7 @ UCF Knights 42 | † |
| 10/16/2010 | UTEP Miners 6 @ UAB 21 | † |
| 10/23/2010 | UAB 24 @ Mississippi State Bulldogs 29 | |
| 10/30/2010 | UAB 50 @ Southern Miss Golden Eagles 49 2OT | † |
| 11/6/2010 | Marshall Thundering Herd 31 @ UAB 17 | † |
| 11/11/2010 | East Carolina Pirates 54 @ UAB 42 | † |
| 11/20/2010 | Memphis Tigers 15 @ UAB 31 | † |
| 11/27/2010 | UAB 23 @ Rice Owls 28 | † |