| 9/4/2010 | Wofford 10 @ Ohio Bobcats 33 | |
| 9/11/2010 | Wofford 34 @ Charleston Southern Buccaneers 23 | |
| 9/18/2010 | Union KY Bulldogs 10 @ Wofford 48 | |
| 10/2/2010 | Furman Paladins 17 @ Wofford 38 | † |
| 10/9/2010 | Wofford 33 @ Georgia Southern Eagles 31 | † |
| 10/16/2010 | Western Carolina Catamounts 14 @ Wofford 45 | † |
| 10/23/2010 | Wofford 28 @ Elon Phoenix 21 | † |
| 10/30/2010 | The Citadel Bulldogs 0 @ Wofford 35 | † |
| 11/6/2010 | Wofford 10 @ Samford Bulldogs 3 | † |
| 11/13/2010 | Wofford 13 @ Appalachian State Mountaineers 43 | † |
| 11/20/2010 | Chattanooga Moccasins 14 @ Wofford 45 | † |
| 12/4/2010 | Wofford 17 @ Jacksonville State Gamecocks 14 | |
| 12/11/2010 | Georgia Southern Eagles 23 @ Wofford 20 | † |