| 9/4/2010 | William & Mary Tribe 23 @ Massachusetts 27 | † |
| 9/11/2010 | Holy Cross Crusaders 7 @ Massachusetts 31 | |
| 9/18/2010 | Massachusetts 37 @ Michigan Wolverines 42 | |
| 9/25/2010 | Massachusetts 26 @ Stony Brook Seawolves 21 | |
| 10/2/2010 | Massachusetts 27 @ Towson Tigers 14 | † |
| 10/16/2010 | Richmond Spiders 11 @ Massachusetts 10 | † |
| 10/23/2010 | New Hampshire Wildcats 39 vs Massachusetts 13 (Foxboro MA) | † |
| 10/30/2010 | Massachusetts 21 @ James Madison Dukes 14 | † |
| 11/6/2010 | Maine Black Bears 24 @ Massachusetts 39 | † |
| 11/13/2010 | Delaware Blue Hens 45 @ Massachusetts 27 | † |
| 11/20/2010 | Massachusetts 34 @ Rhode Island Rams 37 | † |