| 9/2/2010 | Towson 17 @ Indiana Hoosiers 51 | |
| 9/11/2010 | Coastal Carolina Chanticleers 45 @ Towson 47 | |
| 9/18/2010 | Towson 7 @ Villanova Wildcats 43 | † |
| 9/25/2010 | Towson 10 @ Columbia Lions 24 | |
| 10/2/2010 | Massachusetts Minutemen 27 @ Towson 14 | † |
| 10/9/2010 | James Madison Dukes 17 @ Towson 13 | † |
| 10/23/2010 | Towson 6 @ Richmond Spiders 28 | † |
| 10/30/2010 | Rhode Island Rams 30 @ Towson 20 | † |
| 11/6/2010 | Towson 0 @ Delaware Blue Hens 48 | † |
| 11/13/2010 | Maine Black Bears 28 @ Towson 18 | † |
| 11/20/2010 | Towson 19 @ New Hampshire Wildcats 38 | † |