| 9/4/2010 | Arkansas State 26 @ Auburn Tigers 52 | |
| 9/11/2010 | Arkansas State 24 @ UL Lafayette Ragin' Cajuns 31 | † |
| 9/18/2010 | UL Monroe Warhawks 20 @ Arkansas State 34 | † |
| 9/25/2010 | Arkansas State 28 @ Troy Trojans 35 | † |
| 10/2/2010 | Louisville Cardinals 34 @ Arkansas State 24 | |
| 10/9/2010 | Arkansas State 24 @ North Texas Eagles 19 | † |
| 10/16/2010 | Arkansas State 34 @ Indiana Hoosiers 36 | |
| 10/23/2010 | Florida Atlantic Owls 16 @ Arkansas State 37 | † |
| 11/2/2010 | Middle Tenn State Blue Raiders 24 @ Arkansas State 51 | † |
| 11/13/2010 | Western Kentucky Hilltoppers 36 @ Arkansas State 35 1OT | † |
| 11/20/2010 | Arkansas State 19 @ Navy Midshipmen 35 | |
| 11/27/2010 | Arkansas State 24 @ Florida Intl Golden Panthers 31 | † |