| 8/27/2022 | Howard (5-6) | 13 | vs | Alabama State | 23 | Atlanta GA | MEAC | |
| 9/3/2022 | Miles (1-9) | 13 | at | Alabama State | 21 | SIAC (D2) | ||
| 9/10/2022 | Alabama State | 7 | at | UCLA (9-4) | 45 | at P12 | ||
| 9/24/2022 | Prairie View (6-5,5-3) | 24 | at | Alabama State | 15 | |||
| 10/1/2022 | Alabama State | 16 | at | Texas Southern (5-6,4-4) | 13 | |||
| 10/8/2022 | Jackson State (12-1,10-0) | 26 | at | Alabama State | 12 | |||
| 10/15/2022 | Mississippi Valley State (2-9,2-6) | 9 | at | Alabama State | 24 | |||
| 10/29/2022 | Alabama State | 24 | vs | Alabama A&M (4-7,4-4) | 17 | Birmingham AL | ||
| 11/5/2022 | Alabama State | 37 | at | Bethune-Cookman (2-9,2-6) | 22 | |||
| 11/12/2022 | Florida A&M (9-2,7-1) | 21 | at | Alabama State | 14 | |||
| 11/24/2022 | Ark Pine Bluff (3-8,1-7) | 19 | at | Alabama State | 14 |
| vs Alabama State | vs Other Opponents | Alabama State compared to OOs | |
| Record: | 5-6 | 53-60 | |
| Points Scored: | 20.18 | 26.74 | 6.56 |
| Points Allowed: | 18.82 | 28.70 | -9.88 |
| Margin: | 1.36 | -1.96 | -3.32 |
| Total Points: | 39.00 | 55.44 | -16.44 |