| 9/3/2022 | Notre Dame (9-4) | 10 | at | Ohio State | 21 | ND | ||
| 9/10/2022 | Arkansas State (3-9) | 12 | at | Ohio State | 45 | SBC | ||
| 9/17/2022 | Toledo (9-5) | 21 | at | Ohio State | 77 | MAC | ||
| 9/24/2022 | Wisconsin (7-6,4-5) | 21 | at | Ohio State | 52 | |||
| 10/1/2022 | Rutgers (4-8,1-8) | 10 | at | Ohio State | 49 | |||
| 10/8/2022 | Ohio State | 49 | at | Michigan State (5-7,3-6) | 20 | |||
| 10/22/2022 | Iowa (8-5,5-4) | 10 | at | Ohio State | 54 | |||
| 10/29/2022 | Ohio State | 44 | at | Penn State (11-2,7-2) | 31 | |||
| 11/5/2022 | Ohio State | 21 | at | Northwestern (1-11,1-8) | 7 | |||
| 11/12/2022 | Indiana (4-8,2-7) | 14 | at | Ohio State | 56 | |||
| 11/19/2022 | Ohio State | 43 | at | Maryland (8-5,4-5) | 30 | |||
| 11/26/2022 | Michigan (13-1,10-0) | 45 | at | Ohio State | 23 | |||
| 12/31/2022 | Ohio State | 41 | vs | Georgia (15-0) | 42 | Atlanta GA - FBS semifinal | vs SEC |
| vs Ohio State | vs Other Opponents | Ohio State compared to OOs | |
| Record: | 2-11 | 95-60 | |
| Points Scored: | 21.00 | 28.45 | 7.45 |
| Points Allowed: | 44.23 | 21.24 | 22.99 |
| Margin: | -23.23 | 7.21 | 30.44 |
| Total Points: | 65.23 | 49.69 | 15.54 |