| 9/1/2022 | Belhaven | 49 | at | Millsaps | 21 | USASC | ||
| 9/3/2022 | Rhodes | 28 | at | Augustana IL | 34 | @ CCIW | ||
| McMurry | 9 | vs | Birmingham-Southern | 26 | Little Rock AR | vs ASWC | ||
| Centre | at | Hanover | Suspended 10-13 in q3 | @ HCA | ||||
| Austin | 0 | at | Hendrix | 20 | ASWC | |||
| Berry | 31 | at | Maryville | 24 | @ USASC | |||
| St Scholastica | 0 | at | Sewanee | 50 | MIA | |||
| Sul Ross State | 7 | at | Trinity TX | 55 | ASWC | |||
| 9/4/2022 | Centre | 31 | at | Hanover | 29 | @ HCA | ||
| 9/10/2022 | Rhodes | 23 | at | Austin | 7 | @ ASWC | ||
| LaGrange | 10 | at | Berry | 56 | USASC | |||
| Huntingdon AL | 38 | at | Birmingham-Southern | 35 | USASC | |||
| Maryville | 10 | at | Centre | 20 | USASC | |||
| Millsaps | 27 | at | McMurry | 13 | @ ASWC | |||
| Washington and Lee | 44 | at | Sewanee | 0 | ODC | |||
| Wheaton | 16 | at | Trinity TX | 17 | OT | CCIW | ||
| Hendrix | 7 | at | Washington U | 52 | @ CCIW | |||
| 9/17/2022 | Wisconsin-Whitewater | 17 | at | Berry | 3 | WIAC | ||
| Howard Payne | 67 | vs | Hendrix | 10 | Prosper TX | vs ASWC | ||
| Wisconsin-Oshkosh | 41 | at | Millsaps | 17 | WIAC | |||
| Westminster MO | 6 | at | Sewanee | 41 | UMWAC | |||
| Texas Lutheran | 14 | at | Trinity TX | 52 | ASWC | |||
| 9/24/2022 | Point | 14 | at | Birmingham-Southern | 34 | MSC (NAIA) | ||
| Westminster MO | 6 | at | Rhodes | 56 | UMWAC | |||
| Centre | 0 | at | Trine | 17 | @ MIAA | |||
| 10/1/2022 | Berry | 10 | at | Birmingham-Southern | 24 | |||
| Trinity TX | 28 | at | Hendrix | 7 | ||||
| Centre | 21 | at | Rhodes | 7 | ||||
| Millsaps | 30 | at | Sewanee | 27 | ||||
| 10/8/2022 | Rhodes | 0 | at | Berry | 34 | |||
| Sewanee | 16 | at | Centre | 35 | ||||
| Hendrix | 28 | at | Millsaps | 34 | ||||
| Birmingham-Southern | 20 | at | Trinity TX | 23 | ||||
| 10/15/2022 | Millsaps | 0 | at | Birmingham-Southern | 28 | |||
| Berry | 31 | at | Centre | 30 | OT | |||
| Sewanee | 21 | at | Hendrix | 48 | ||||
| Trinity TX | 45 | at | Rhodes | 0 | ||||
| 10/22/2022 | Centre | 45 | at | Hendrix | 42 | |||
| Rhodes | 31 | at | Millsaps | 7 | ||||
| Birmingham-Southern | 47 | at | Sewanee | 3 | ||||
| Berry | 14 | at | Trinity TX | 21 | ||||
| 10/29/2022 | Millsaps | 0 | at | Berry | 56 | |||
| Hendrix | 7 | at | Birmingham-Southern | 30 | ||||
| Trinity TX | 41 | at | Centre | 21 | ||||
| Sewanee | 6 | at | Rhodes | 33 | ||||
| 11/5/2022 | Centre | 21 | at | Birmingham-Southern | 42 | |||
| Rhodes | 0 | vs | Hendrix | 6 | Little Rock AR | |||
| Trinity TX | 53 | at | Millsaps | 7 | ||||
| Berry | 63 | at | Sewanee | 14 | ||||
| 11/12/2022 | Hendrix | 8 | at | Berry | 55 | |||
| Millsaps | 3 | at | Centre | 57 | ||||
| Birmingham-Southern | 3 | at | Rhodes | 20 | ||||
| Sewanee | 0 | at | Trinity TX | 38 | ||||
| 11/19/2022 | Hardin-Simmons | 7 | at | Trinity TX | 14 | D3 Championship Round 1 | ASWC | |
| 11/26/2022 | Mary Hardin-Baylor | 24 | at | Trinity TX | 17 | D3 Playoffs Round 2 | ASWC |