| 9/3/2022 | Hardin-Simmons | 79 | at | Wayland Baptist (2-8) | 14 | at Soon | ||
| 9/17/2022 | Hardin-Simmons | 41 | at | Wisconsin-Platteville (5-5) | 0 | at WIAC | ||
| 9/24/2022 | Mary Hardin-Baylor (12-2,8-0) | 50 | at | Hardin-Simmons | 20 | |||
| 10/1/2022 | Hardin-Simmons | 45 | at | McMurry (1-9,1-7) | 13 | |||
| 10/8/2022 | Sul Ross State (4-6,4-4) | 35 | at | Hardin-Simmons | 70 | |||
| 10/15/2022 | East Texas Baptist (5-5,4-4) | 7 | at | Hardin-Simmons | 27 | |||
| 10/22/2022 | Hardin-Simmons | 68 | at | Southwestern Texas (3-7,2-6) | 0 | |||
| 10/29/2022 | Howard Payne (7-3,6-2) | 19 | at | Hardin-Simmons | 28 | |||
| 11/5/2022 | Austin (1-9,1-7) | 3 | at | Hardin-Simmons | 31 | |||
| 11/12/2022 | Hardin-Simmons | 45 | at | Texas Lutheran (4-6,3-5) | 16 | |||
| 11/19/2022 | Hardin-Simmons | 7 | at | Trinity TX (11-1) | 14 | D3 Championship Round 1 | at SAA |
| vs Hardin-Simmons | vs Other Opponents | Hardin-Simmons compared to OOs | |
| Record: | 2-9 | 53-52 | |
| Points Scored: | 15.55 | 27.24 | 11.69 |
| Points Allowed: | 41.91 | 26.56 | 15.35 |
| Margin: | -26.36 | 0.68 | 27.04 |
| Total Points: | 57.46 | 53.80 | 3.66 |