| 9/10/2022 | Hendrix (3-7) | 7 | at | Washington U | 52 | SAA | ||
| 9/17/2022 | Millikin (4-6,3-6) | 7 | at | Washington U | 54 | |||
| 9/24/2022 | Washington U | 45 | at | Carthage (3-7,3-6) | 16 | |||
| 10/1/2022 | Washington U | 56 | at | North Park (1-9,1-8) | 21 | |||
| 10/8/2022 | Illinois Wesleyan (6-4,5-4) | 14 | at | Washington U | 59 | |||
| 10/15/2022 | Washington U | 49 | at | Augustana IL (5-5,4-5) | 28 | |||
| 10/22/2022 | North Central (15-0,9-0) | 31 | at | Washington U | 0 | |||
| 10/29/2022 | Washington U | 49 | at | Elmhurst (0-10,0-9) | 6 | |||
| 11/5/2022 | Wheaton (8-3,8-1) | 42 | at | Washington U | 35 | |||
| 11/12/2022 | Washington U | 37 | at | Carroll WI (6-4,5-4) | 7 | |||
| 11/19/2022 | Wisconsin-River Falls (7-4) | 31 | vs | Washington U | 24 | Isthmus Bowl - Madison WI | WIAC |
| vs Washington U | vs Other Opponents | Washington U compared to OOs | |
| Record: | 3-8 | 55-51 | |
| Points Scored: | 19.09 | 30.26 | 11.17 |
| Points Allowed: | 41.82 | 27.90 | 13.92 |
| Margin: | -22.73 | 2.36 | 25.09 |
| Total Points: | 60.91 | 58.16 | 2.75 |