| 9/10/2022 | Wheaton | 16 | at | Trinity TX (11-1) | 17 | OT | at SAA | |
| 9/17/2022 | Illinois Wesleyan (6-4,5-4) | 7 | at | Wheaton | 42 | |||
| 9/24/2022 | Wheaton | 38 | at | Augustana IL (5-5,4-5) | 28 | |||
| 10/1/2022 | Wheaton | 20 | at | North Central (15-0,9-0) | 33 | |||
| 10/8/2022 | Elmhurst (0-10,0-9) | 0 | at | Wheaton | 56 | |||
| 10/15/2022 | Wheaton | 59 | at | Carthage (3-7,3-6) | 24 | |||
| 10/22/2022 | Carroll WI (6-4,5-4) | 9 | at | Wheaton | 61 | |||
| 10/29/2022 | Millikin (4-6,3-6) | 3 | at | Wheaton | 69 | |||
| 11/5/2022 | Wheaton | 42 | at | Washington U (8-3,7-2) | 35 | |||
| 11/12/2022 | North Park (1-9,1-8) | 14 | at | Wheaton | 54 | |||
| 11/19/2022 | Bethel MN (10-3) | 34 | at | Wheaton | 32 | D3 Championship Round 1 | MIA |
| vs Wheaton | vs Other Opponents | Wheaton compared to OOs | |
| Record: | 3-8 | 66-44 | |
| Points Scored: | 18.55 | 30.99 | 12.44 |
| Points Allowed: | 44.45 | 25.19 | 19.26 |
| Margin: | -25.90 | 5.80 | 31.70 |
| Total Points: | 63.00 | 56.18 | 6.82 |