| 9/1/2022 | Anderson (1-9) | 0 | at | Trine | 38 | HCA | ||
| 9/10/2022 | Trine | 24 | at | Rose-Hulman (6-4) | 23 | at HCA | ||
| 9/17/2022 | Trine | 55 | at | Franklin (4-6) | 21 | at HCA | ||
| 9/24/2022 | Centre (6-4) | 0 | at | Trine | 17 | SAA | ||
| 10/1/2022 | Alma (11-1,6-0) | 40 | at | Trine | 21 | |||
| 10/8/2022 | Trine | 27 | at | Adrian (6-4,3-3) | 21 | |||
| 10/15/2022 | Trine | 39 | at | Olivet (5-5,1-5) | 37 | 3OT | ||
| 10/22/2022 | Albion (9-1,5-1) | 20 | at | Trine | 19 | |||
| 11/5/2022 | Hope (6-4,3-3) | 28 | at | Trine | 21 | |||
| 11/12/2022 | Trine | 42 | at | Kalamazoo (3-7,0-6) | 19 |
| vs Trine | vs Other Opponents | Trine compared to OOs | |
| Record: | 3-7 | 54-38 | |
| Points Scored: | 20.90 | 30.49 | 9.59 |
| Points Allowed: | 30.30 | 25.26 | 5.04 |
| Margin: | -9.40 | 5.23 | 14.63 |
| Total Points: | 51.20 | 55.75 | -4.55 |