9/2/2022 | Ursinus | 59 | at | Alvernia | 27 | | | Cen |
| Lebanon Valley | 7 | at | Franklin & Marshall | 26 | | | @ Cen |
| Fairleigh Dickinson-Florham | 17 | at | Merchant Marine | 7 | | | @ NEWMAC |
| Albright | 0 | at | Salisbury | 49 | | | @ NJAC |
9/3/2022 | Misericordia | 14 | at | Alfred State | 17 | | | @ ECFC |
| Westminster PA | 8 | at | Delaware Valley | 22 | | | TPAC |
| Wilkes | 48 | at | Keystone | 21 | | | @ ECFC |
| Susquehanna | 45 | at | Lycoming | 16 | | | Cen |
| Stevenson | 25 | at | St Vincent | 21 | | | @ TPAC |
| Rowan | 42 | at | Widener | 20 | | | NJAC |
9/9/2022 | William Paterson | 21 | at | Fairleigh Dickinson-Florham | 28 | | | NJAC |
9/10/2022 | Western Connecticut | 28 | at | Albright | 14 | | | MSCAC |
| Widener | 31 | at | Hampden-Sydney | 27 | | | @ ODC |
| King's | 17 | at | Hartwick | 10 | | | @ E8 |
| Lycoming | 21 | at | Lebanon Valley | 20 | | | |
| Keystone | 20 | at | Misericordia | 38 | | | ECFC |
| Delaware Valley | 14 | at | Montclair State | 6 | | | @ NJAC |
| Alvernia | 38 | at | Oberlin | 35 | | | @ NCA |
| Salisbury | 21 | at | Stevenson | 35 | | | NJAC |
9/17/2022 | Misericordia | 27 | at | Albright | 21 | | | |
| Lebanon Valley | 17 | at | Fairleigh Dickinson-Florham | 14 | OT | | |
| Delaware Valley | 26 | at | King's | 6 | | | |
| Alvernia | 18 | at | Stevenson | 40 | | | |
| Widener | 20 | at | Wilkes | 44 | | | |
9/24/2022 | Lycoming | 45 | at | Albright | 0 | | | |
| Misericordia | 0 | at | Delaware Valley | 41 | | | |
| King's | 27 | at | Fairleigh Dickinson-Florham | 23 | | | |
| Wilkes | 19 | at | Lebanon Valley | 24 | | | |
| Stevenson | 30 | at | Widener | 14 | | | |
10/1/2022 | Lebanon Valley | 32 | at | Alvernia | 6 | | | |
| King's | 28 | at | Lycoming | 23 | | | |
| Fairleigh Dickinson-Florham | 28 | at | Misericordia | 14 | | | |
| Delaware Valley | 26 | at | Stevenson | 7 | | | |
| Albright | 0 | at | Wilkes | 27 | | | |
10/8/2022 | Wilkes | 35 | at | Alvernia | 14 | | | |
| Lycoming | 0 | at | Delaware Valley | 21 | | | |
| Widener | 17 | at | Fairleigh Dickinson-Florham | 30 | | | |
| Stevenson | 7 | at | King's | 20 | | | |
| Lebanon Valley | 47 | at | Misericordia | 12 | | | |
10/15/2022 | King's | 27 | at | Albright | 21 | | | |
| Delaware Valley | 34 | at | Lebanon Valley | 10 | | | |
| Stevenson | 24 | at | Lycoming | 10 | | | |
| Alvernia | 19 | at | Widener | 16 | | | |
| Misericordia | 0 | at | Wilkes | 28 | | | |
10/22/2022 | Wilkes | 14 | at | Delaware Valley | 27 | | | |
| Lebanon Valley | 24 | at | King's | 34 | | | |
| Alvernia | 10 | at | Lycoming | 42 | | | |
| Fairleigh Dickinson-Florham | 7 | at | Stevenson | 20 | | | |
| Albright | 28 | at | Widener | 34 | | | |
10/29/2022 | King's | 41 | at | Alvernia | 14 | | | |
| Albright | 2 | at | Fairleigh Dickinson-Florham | 10 | | | |
| Widener | 26 | at | Lebanon Valley | 20 | | | |
| Stevenson | 44 | at | Misericordia | 7 | | | |
| Lycoming | 7 | at | Wilkes | 24 | | | |
11/5/2022 | Alvernia | 21 | at | Albright | 14 | | | |
| Fairleigh Dickinson-Florham | 7 | at | Delaware Valley | 42 | | | |
| Misericordia | 0 | at | King's | 14 | | | |
| Widener | 16 | at | Lycoming | 28 | | | |
| Wilkes | 0 | at | Stevenson | 28 | | | |
11/12/2022 | Fairleigh Dickinson-Florham | 31 | at | Alvernia | 7 | | | |
| Albright | 24 | at | Lebanon Valley | 41 | | | |
| Lycoming | 14 | at | Misericordia | 21 | | | |
| Delaware Valley | 34 | at | Widener | 7 | | | |
| King's | 42 | at | Wilkes | 58 | | | |
11/19/2022 | Gallaudet | 0 | at | Delaware Valley | 59 | | D3 Championship Round 1 | ECFC |
| Fairleigh Dickinson-Florham | 14 | at | Grove City | 31 | | | @ TPAC |
| Stevenson | 7 | at | Johns Hopkins | 27 | | | @ Cen |
| Ursinus | 24 | at | King's | 13 | | | Cen |
| Muhlenberg | 48 | at | Lebanon Valley | 21 | | | Cen |
11/26/2022 | Randolph-Macon | 32 | at | Delaware Valley | 39 | | D3 Playoffs Round 2 | ODC |
12/3/2022 | Mount Union | 22 | at | Delaware Valley | 6 | | D3 Quarterfinals | OAC |