| 9/2/2022 | Lebanon Valley (5-6) | 7 | at | Franklin & Marshall | 26 | MidAC | ||
| 9/10/2022 | Franklin & Marshall | 36 | at | Susquehanna (10-1,9-0) | 39 | |||
| 9/17/2022 | Franklin & Marshall | 35 | at | McDaniel (3-7,3-6) | 3 | |||
| 9/24/2022 | Ursinus (9-2,7-2) | 22 | at | Franklin & Marshall | 7 | |||
| 10/1/2022 | Johns Hopkins (10-1,8-1) | 43 | at | Franklin & Marshall | 26 | |||
| 10/15/2022 | Franklin & Marshall | 38 | at | Juniata (0-10,0-9) | 13 | |||
| 10/22/2022 | Dickinson (3-7,3-6) | 17 | at | Franklin & Marshall | 28 | |||
| 10/29/2022 | Franklin & Marshall | 21 | at | Muhlenberg (7-4,6-3) | 28 | |||
| 11/5/2022 | Moravian (3-7,3-6) | 7 | at | Franklin & Marshall | 56 | |||
| 11/12/2022 | Franklin & Marshall | 31 | at | Gettysburg (1-9,1-8) | 14 |
| vs Franklin & Marshall | vs Other Opponents | Franklin & Marshall compared to OOs | |
| Record: | 4-6 | 47-48 | |
| Points Scored: | 19.30 | 26.83 | 7.53 |
| Points Allowed: | 30.40 | 26.68 | 3.72 |
| Margin: | -11.10 | 0.15 | 11.25 |
| Total Points: | 49.70 | 53.51 | -3.81 |