| 9/3/2022 | Wilkes (7-3) | 48 | at | Keystone | 21 | MidAC | ||
| 9/10/2022 | Keystone | 20 | at | Misericordia (3-7) | 38 | at MidAC | ||
| 9/17/2022 | Keystone | 20 | at | William Paterson (5-5) | 27 | at NJAC | ||
| 9/24/2022 | Hobart (7-4) | 65 | at | Keystone | 6 | LL | ||
| 10/1/2022 | Gallaudet (7-3,5-1) | 52 | at | Keystone | 44 | |||
| 10/8/2022 | Keystone | 33 | at | Alfred State (5-5,3-3) | 42 | |||
| 10/15/2022 | Keystone | 41 | at | Anna Maria (5-4,3-3) | 39 | |||
| 10/22/2022 | Castleton State (5-5,4-2) | 35 | at | Keystone | 20 | |||
| 11/5/2022 | SUNY-Maritime (3-7,2-4) | 20 | at | Keystone | 21 | |||
| 11/12/2022 | Keystone | 45 | at | Dean (1-9,1-5) | 44 | OT |
| vs Keystone | vs Other Opponents | Keystone compared to OOs | |
| Record: | 7-3 | 41-49 | |
| Points Scored: | 41.00 | 22.80 | -18.20 |
| Points Allowed: | 27.10 | 25.54 | 1.56 |
| Margin: | 13.90 | -2.74 | -16.64 |
| Total Points: | 68.10 | 48.34 | 19.76 |