| 9/3/2022 | Stevenson (8-3) | 25 | at | St Vincent | 21 | MidAC | ||
| 9/10/2022 | Washington & Jefferson (9-2,7-2) | 52 | at | St Vincent | 21 | |||
| 9/17/2022 | Thiel (1-9,1-8) | 16 | at | St Vincent | 24 | |||
| 9/24/2022 | St Vincent | 7 | at | Grove City (8-3,6-3) | 42 | |||
| 10/8/2022 | St Vincent | 21 | at | Case Western Reserve (6-4,6-3) | 45 | |||
| 10/15/2022 | Geneva (3-7,3-6) | 25 | at | St Vincent | 41 | |||
| 10/22/2022 | St Vincent | 52 | at | Allegheny (3-7,3-6) | 35 | |||
| 10/29/2022 | St Vincent | 12 | at | Carnegie Mellon (11-1,8-0) | 30 | |||
| 11/5/2022 | Waynesburg (4-6,3-6) | 16 | at | St Vincent | 53 | |||
| 11/12/2022 | Bethany WV (1-9,0-9) | 7 | at | St Vincent | 36 |
| vs St Vincent | vs Other Opponents | St Vincent compared to OOs | |
| Record: | 5-5 | 49-46 | |
| Points Scored: | 29.30 | 24.64 | -4.66 |
| Points Allowed: | 28.80 | 24.42 | 4.38 |
| Margin: | 0.50 | 0.22 | -0.28 |
| Total Points: | 58.10 | 49.06 | 9.04 |