| 9/3/2022 | Muhlenberg | 13 | at | Mary Hardin-Baylor (12-2) | 62 | at ASWC | ||
| 9/10/2022 | Dickinson (3-7,3-6) | 21 | at | Muhlenberg | 34 | |||
| 9/17/2022 | Muhlenberg | 28 | at | Ursinus (9-2,7-2) | 35 | |||
| 9/24/2022 | McDaniel (3-7,3-6) | 7 | at | Muhlenberg | 41 | |||
| 10/1/2022 | Gettysburg (1-9,1-8) | 17 | at | Muhlenberg | 56 | |||
| 10/14/2022 | Muhlenberg | 27 | at | Johns Hopkins (10-1,8-1) | 34 | |||
| 10/22/2022 | Muhlenberg | 57 | at | Juniata (0-10,0-9) | 12 | |||
| 10/29/2022 | Franklin & Marshall (6-4,5-4) | 21 | at | Muhlenberg | 28 | |||
| 11/5/2022 | Susquehanna (10-1,9-0) | 28 | at | Muhlenberg | 24 | |||
| 11/12/2022 | Muhlenberg | 37 | at | Moravian (3-7,3-6) | 10 | |||
| 11/19/2022 | Muhlenberg | 48 | at | Lebanon Valley (5-6) | 21 | at MidAC |
| vs Muhlenberg | vs Other Opponents | Muhlenberg compared to OOs | |
| Record: | 4-7 | 58-49 | |
| Points Scored: | 24.36 | 27.69 | 3.33 |
| Points Allowed: | 35.73 | 24.40 | 11.33 |
| Margin: | -11.37 | 3.29 | 14.66 |
| Total Points: | 60.09 | 52.09 | 8.00 |