| 9/3/2022 | Hampden-Sydney | 48 | at | Wabash (7-3) | 52 | at NCA | ||
| 9/10/2022 | Widener (3-7) | 31 | at | Hampden-Sydney | 27 | MidAC | ||
| 9/17/2022 | Greensboro (1-9) | 28 | at | Hampden-Sydney | 70 | USASC | ||
| 10/1/2022 | Hampden-Sydney | 17 | at | Bridgewater VA (9-1,6-1) | 27 | |||
| 10/8/2022 | Hampden-Sydney | 35 | at | Ferrum (1-9,1-6) | 16 | |||
| 10/15/2022 | Averett (3-7,1-6) | 26 | at | Hampden-Sydney | 37 | |||
| 10/22/2022 | Hampden-Sydney | 44 | at | Washington and Lee (5-5,3-4) | 43 | OT | ||
| 10/29/2022 | Guilford (2-8,1-6) | 21 | at | Hampden-Sydney | 28 | |||
| 11/5/2022 | Hampden-Sydney | 7 | at | Shenandoah (8-2,5-2) | 23 | |||
| 11/12/2022 | Randolph-Macon (11-1,7-0) | 38 | at | Hampden-Sydney | 17 |
| vs Hampden-Sydney | vs Other Opponents | Hampden-Sydney compared to OOs | |
| Record: | 5-5 | 45-47 | |
| Points Scored: | 30.50 | 26.23 | -4.27 |
| Points Allowed: | 33.00 | 26.27 | 6.73 |
| Margin: | -2.50 | -0.04 | 2.46 |
| Total Points: | 63.50 | 52.50 | 11.00 |