D3
9 Jan 2023 21:04:24
| 9/1/2022 | Anderson | 0 | at | Trine | 38 | | | @ MIAA |
| 9/3/2022 | Rose-Hulman | 14 | at | DePauw | 17 | | | @ NCA |
| Centre | | at | Hanover | | | Suspended 10-13 in q3 | SAA |
| Bluffton | 26 | at | Kenyon | 33 | | | @ NCA |
| Defiance | 0 | at | Mount Union | 65 | | | @ OAC |
| Baldwin-Wallace | 28 | at | Mt St Joseph | 31 | | | OAC |
| Manchester | 23 | at | North Park | 14 | | | @ CCIW |
| Franklin | 31 | at | Olivet | 35 | | | @ MIAA |
| 9/4/2022 | Centre | 31 | at | Hanover | 29 | | | SAA |
| 9/10/2022 | Hanover | 0 | at | Adrian | 33 | | | @ MIAA |
| Bluffton | 2 | at | Albion | 51 | | | @ MIAA |
| Mt St Joseph | 43 | at | Alfred | 37 | | | @ E8 |
| Manchester | 7 | at | Alma | 49 | | | @ MIAA |
| DePauw | 55 | at | Anderson | 0 | | | NCA |
| Franklin | 16 | at | Aurora | 49 | | | @ NAC |
| Trine | 24 | at | Rose-Hulman | 23 | | | MIAA |
| 9/17/2022 | Alma | 45 | at | Anderson | 7 | | | MIAA |
| Adrian | 58 | at | Bluffton | 23 | | | MIAA |
| Kalamazoo | 42 | at | Defiance | 23 | | | MIAA |
| Trine | 55 | at | Franklin | 21 | | | MIAA |
| Manchester | 22 | at | Greenville | 49 | | | @ UMWAC |
| Olivet | 31 | at | Hanover | 28 | | | MIAA |
| Hope | 28 | at | Mt St Joseph | 33 | | | MIAA |
| Albion | 49 | at | Rose-Hulman | 17 | | | MIAA |
| 9/24/2022 | Defiance | 33 | at | Alfred State | 42 | | | @ ECFC |
| 10/1/2022 | Rose-Hulman | 45 | at | Anderson | 7 | | | |
| Franklin | 37 | at | Bluffton | 27 | | | |
| Hanover | 37 | at | Defiance | 20 | | | |
| Mt St Joseph | 55 | at | Manchester | 20 | | | |
| 10/8/2022 | Anderson | 14 | at | Franklin | 54 | | | |
| Bluffton | 21 | at | Hanover | 63 | | | |
| Defiance | 35 | at | Mt St Joseph | 55 | | | |
| Manchester | 14 | at | Rose-Hulman | 48 | | | |
| 10/15/2022 | Mt St Joseph | 59 | at | Anderson | 3 | | | |
| Rose-Hulman | 48 | at | Bluffton | 20 | | | |
| Defiance | 19 | at | Franklin | 48 | | | |
| Hanover | 51 | at | Manchester | 20 | | | |
| 10/22/2022 | Anderson | 22 | at | Defiance | 32 | | | |
| Mt St Joseph | 44 | at | Hanover | 29 | | | |
| Bluffton | 46 | at | Manchester | 44 | 5OT | | |
| Franklin | 0 | at | Rose-Hulman | 49 | | | |
| 10/29/2022 | Hanover | 62 | at | Anderson | 3 | | | |
| Franklin | 24 | at | Manchester | 6 | | | |
| Bluffton | 21 | at | Mt St Joseph | 70 | | | |
| Defiance | 35 | at | Rose-Hulman | 76 | | | |
| 11/5/2022 | Anderson | 9 | at | Bluffton | 27 | | | |
| Manchester | 21 | at | Defiance | 24 | | | |
| Mt St Joseph | 27 | at | Franklin | 20 | | | |
| Rose-Hulman | 47 | at | Hanover | 17 | | | |
| 11/12/2022 | Manchester | 12 | at | Anderson | 19 | | | |
| Defiance | 17 | at | Bluffton | 14 | | | |
| Hanover | 24 | at | Franklin | 3 | | | |
| Rose-Hulman | 31 | at | Mt St Joseph | 40 | | | |
| 11/19/2022 | Mt St Joseph | 21 | at | Alma | 41 | | D3 Championship Round 1 | @ MIAA |