| 9/3/2022 | Adrian | 0 | at | Heidelberg (7-3) | 31 | at OAC | ||
| 9/10/2022 | Hanover (5-5) | 0 | at | Adrian | 33 | HCA | ||
| 9/17/2022 | Adrian | 58 | at | Bluffton (2-8) | 23 | at HCA | ||
| 9/24/2022 | Finlandia (0-10) | 13 | at | Adrian | 73 | UMWAC | ||
| 10/1/2022 | Adrian | 22 | at | Hope (6-4,3-3) | 10 | |||
| 10/8/2022 | Trine (7-3,3-3) | 27 | at | Adrian | 21 | |||
| 10/15/2022 | Kalamazoo (3-7,0-6) | 17 | at | Adrian | 42 | |||
| 10/29/2022 | Adrian | 9 | at | Albion (9-1,5-1) | 37 | |||
| 11/5/2022 | Adrian | 10 | at | Alma (11-1,6-0) | 30 | |||
| 11/12/2022 | Olivet (5-5,1-5) | 0 | at | Adrian | 28 |
| vs Adrian | vs Other Opponents | Adrian compared to OOs | |
| Record: | 4-6 | 51-41 | |
| Points Scored: | 18.80 | 30.02 | 11.22 |
| Points Allowed: | 29.60 | 26.30 | 3.30 |
| Margin: | -10.80 | 3.72 | 14.52 |
| Total Points: | 48.40 | 56.32 | -7.92 |