| 9/3/2022 | Greenville | 14 | at | Millikin (4-6) | 28 | at CCIW | ||
| 9/10/2022 | Rockford (1-9) | 30 | at | Greenville | 40 | NAC | ||
| 9/17/2022 | Manchester (1-9) | 22 | at | Greenville | 49 | HCA | ||
| 9/24/2022 | Olivet (5-5) | 63 | at | Greenville | 7 | MIAA | ||
| 10/1/2022 | Martin Luther (2-8,2-4) | 27 | at | Greenville | 30 | |||
| 10/8/2022 | Greenville | 35 | at | Northwestern MN (6-5,6-0) | 41 | |||
| 10/15/2022 | Westminster MO (1-9,1-5) | 0 | at | Greenville | 52 | |||
| 10/29/2022 | Greenville | 48 | at | Crown (3-7,3-3) | 6 | |||
| 11/5/2022 | Finlandia (0-10,0-6) | 7 | at | Greenville | 45 | |||
| 11/12/2022 | Greenville | 43 | at | Minnesota-Morris (5-5,4-2) | 25 |
| vs Greenville | vs Other Opponents | Greenville compared to OOs | |
| Record: | 3-7 | 25-66 | |
| Points Scored: | 24.90 | 17.63 | -7.27 |
| Points Allowed: | 36.30 | 34.76 | 1.54 |
| Margin: | -11.40 | -17.13 | -5.73 |
| Total Points: | 61.20 | 52.39 | 8.81 |