| 9/3/2022 | Alma | 16 | at | Ohio Northern (3-7) | 13 | OT | at OAC | |
| 9/10/2022 | Manchester (1-9) | 7 | at | Alma | 49 | HCA | ||
| 9/17/2022 | Alma | 45 | at | Anderson (1-9) | 7 | at HCA | ||
| 9/24/2022 | Martin Luther (2-8) | 0 | at | Alma | 69 | UMWAC | ||
| 10/1/2022 | Alma | 40 | at | Trine (7-3,3-3) | 21 | |||
| 10/15/2022 | Hope (6-4,3-3) | 26 | at | Alma | 28 | |||
| 10/22/2022 | Alma | 45 | at | Kalamazoo (3-7,0-6) | 21 | |||
| 10/29/2022 | Alma | 49 | at | Olivet (5-5,1-5) | 35 | |||
| 11/5/2022 | Adrian (6-4,3-3) | 10 | at | Alma | 30 | |||
| 11/12/2022 | Albion (9-1,5-1) | 31 | at | Alma | 34 | |||
| 11/19/2022 | Mt St Joseph (10-1) | 21 | at | Alma | 41 | D3 Championship Round 1 | HCA | |
| 11/26/2022 | Aurora (11-2) | 48 | at | Alma | 26 | D3 Playoffs Round 2 | NAC |
| vs Alma | vs Other Opponents | Alma compared to OOs | |
| Record: | 1-11 | 63-49 | |
| Points Scored: | 20.00 | 28.82 | 8.82 |
| Points Allowed: | 39.33 | 25.17 | 14.16 |
| Margin: | -19.33 | 3.65 | 22.98 |
| Total Points: | 59.33 | 53.99 | 5.34 |