| 9/3/2022 | Aurora (11-2) | 34 | at | Hope | 38 | NAC | ||
| 9/10/2022 | Coe (7-3) | 24 | at | Hope | 33 | ARC | ||
| 9/17/2022 | Hope | 28 | at | Mt St Joseph (10-1) | 33 | at HCA | ||
| 9/24/2022 | Hope | 56 | at | Northwestern MN (6-5) | 7 | at UMWAC | ||
| 10/1/2022 | Adrian (6-4,3-3) | 22 | at | Hope | 10 | |||
| 10/8/2022 | Hope | 10 | at | Albion (9-1,5-1) | 30 | |||
| 10/15/2022 | Hope | 26 | at | Alma (11-1,6-0) | 28 | |||
| 10/22/2022 | Olivet (5-5,1-5) | 0 | at | Hope | 23 | |||
| 10/29/2022 | Kalamazoo (3-7,0-6) | 20 | at | Hope | 66 | |||
| 11/5/2022 | Hope | 28 | at | Trine (7-3,3-3) | 21 |
| vs Hope | vs Other Opponents | Hope compared to OOs | |
| Record: | 4-6 | 71-26 | |
| Points Scored: | 21.90 | 35.41 | 13.51 |
| Points Allowed: | 31.80 | 21.37 | 10.43 |
| Margin: | -9.90 | 14.04 | 23.94 |
| Total Points: | 53.70 | 56.78 | -3.08 |