| 9/3/2022 | Rose-Hulman (6-4) | 14 | at | DePauw | 17 | HCA | ||
| 9/10/2022 | DePauw | 55 | at | Anderson (1-9) | 0 | at HCA | ||
| 9/17/2022 | DePauw | 44 | at | Hiram (2-8,1-7) | 0 | |||
| 9/24/2022 | Wooster (6-4,4-4) | 0 | at | DePauw | 59 | |||
| 10/1/2022 | DePauw | 17 | at | Denison (8-2,6-2) | 13 | |||
| 10/8/2022 | Wittenberg (5-5,4-4) | 30 | at | DePauw | 7 | |||
| 10/22/2022 | DePauw | 22 | at | Ohio Wesleyan (6-4,6-2) | 21 | |||
| 10/29/2022 | DePauw | 58 | at | Kenyon (3-7,2-6) | 35 | |||
| 11/5/2022 | Oberlin (0-10,0-8) | 0 | at | DePauw | 72 | |||
| 11/12/2022 | Wabash (7-3,6-2) | 14 | at | DePauw | 49 | |||
| 11/19/2022 | DePauw | 14 | at | Carnegie Mellon (11-1) | 45 | D3 Championship Round 1 | at TPAC |
| vs DePauw | vs Other Opponents | DePauw compared to OOs | |
| Record: | 2-9 | 53-48 | |
| Points Scored: | 15.64 | 30.47 | 14.83 |
| Points Allowed: | 37.64 | 29.28 | 8.36 |
| Margin: | -22.00 | 1.19 | 23.19 |
| Total Points: | 53.28 | 59.75 | -6.47 |