| 9/3/2022 | Centre | at | Hanover (5-5) | Suspended 10-13 in q3 | at HCA | |||
| 9/4/2022 | Centre | 31 | at | Hanover (5-5) | 29 | at HCA | ||
| 9/10/2022 | Maryville (5-5) | 10 | at | Centre | 20 | USASC | ||
| 9/24/2022 | Centre | 0 | at | Trine (7-3) | 17 | at MIAA | ||
| 10/1/2022 | Centre | 21 | at | Rhodes (5-5,3-4) | 7 | |||
| 10/8/2022 | Sewanee (2-8,0-7) | 16 | at | Centre | 35 | |||
| 10/15/2022 | Berry (7-3,5-2) | 31 | at | Centre | 30 | OT | ||
| 10/22/2022 | Centre | 45 | at | Hendrix (3-7,2-5) | 42 | |||
| 10/29/2022 | Trinity TX (11-1,7-0) | 41 | at | Centre | 21 | |||
| 11/5/2022 | Centre | 21 | at | Birmingham-Southern (7-3,5-2) | 42 | |||
| 11/12/2022 | Millsaps (3-7,2-5) | 3 | at | Centre | 57 |
| vs Centre | vs Other Opponents | Centre compared to OOs | |
| Record: | 4-6 | 56-45 | |
| Points Scored: | 23.80 | 28.04 | 4.24 |
| Points Allowed: | 28.10 | 22.90 | 5.20 |
| Margin: | -4.30 | 5.14 | 9.44 |
| Total Points: | 51.90 | 50.94 | 0.96 |