| 9/1/2022 | Notre Dame OH | 14 | at | Ashland | 31 | MtnE | ||
| 9/3/2022 | Hillsdale | 35 | at | Lake Erie | 31 | |||
| Kentucky Wesleyan | 13 | at | Northwood | 55 | ||||
| Findlay | 14 | at | Ohio Dominican | 28 | ||||
| Tiffin | 42 | at | Walsh | 0 | ||||
| 9/10/2022 | Ashland | 28 | at | Findlay | 3 | |||
| Walsh | 17 | at | Hillsdale | 35 | ||||
| Lake Erie | 26 | at | Kentucky Wesleyan | 21 | ||||
| Madonna | 0 | at | Northwood | 38 | MSFA (NAIA) | |||
| Ohio Dominican | 13 | at | Tiffin | 28 | ||||
| 9/17/2022 | Southwest Baptist | 35 | at | Findlay | 52 | GLV | ||
| Truman State | 21 | at | Hillsdale | 13 | GLV | |||
| Missouri S&T | 6 | at | Kentucky Wesleyan | 11 | GLV | |||
| McKendree | 38 | at | Lake Erie | 37 | GLV | |||
| Saginaw Valley State | 35 | at | Northwood | 14 | GLIAC | |||
| William Jewell | 21 | at | Ohio Dominican | 31 | GLV | |||
| Indianapolis | 27 | at | Tiffin | 20 | GLV | |||
| Quincy | 28 | at | Walsh | 13 | GLV | |||
| 9/24/2022 | Northwood | 17 | at | Davenport | 51 | @ GLIAC | ||
| Walsh | 10 | at | McKendree | 46 | @ GLV | |||
| Hillsdale | 17 | at | Missouri S&T | 10 | @ GLV | |||
| Findlay | 27 | at | North Greenville | 34 | @ GSC | |||
| Indianapolis | 44 | at | Ohio Dominican | 38 | GLV | |||
| Ashland | 34 | at | Quincy | 14 | @ GLV | |||
| Lake Erie | 31 | at | Southwest Baptist | 52 | @ GLV | |||
| Tiffin | 17 | at | Truman State | 18 | OT | @ GLV | ||
| Kentucky Wesleyan | 17 | at | William Jewell | 24 | @ GLV | |||
| 10/1/2022 | Northwood | 17 | at | Ashland | 56 | |||
| Ferris State | 38 | at | Findlay | 7 | GLIAC | |||
| Hillsdale | 27 | at | Kentucky Wesleyan | 31 | ||||
| Walsh | 0 | at | Ohio Dominican | 21 | ||||
| Lake Erie | 27 | at | Tiffin | 52 | ||||
| 10/8/2022 | Northwood | 14 | at | Findlay | 34 | |||
| Tiffin | 41 | at | Hillsdale | 0 | ||||
| Ohio Dominican | 38 | at | Lake Erie | 7 | ||||
| Kentucky Wesleyan | 9 | at | Quincy | 46 | @ GLV | |||
| Ashland | 35 | at | Walsh | 0 | ||||
| 10/15/2022 | Ohio Dominican | 7 | at | Ashland | 14 | |||
| Findlay | 44 | at | Kentucky Wesleyan | 7 | ||||
| Hillsdale | 41 | at | Northwood | 7 | ||||
| Lake Erie | 22 | at | Walsh | 15 | OT | |||
| 10/22/2022 | Tiffin | 20 | at | Ashland | 28 | |||
| Findlay | 41 | at | Hillsdale | 20 | ||||
| Northwood | 18 | at | Lake Erie | 21 | ||||
| Kentucky Wesleyan | 7 | at | Ohio Dominican | 49 | ||||
| 10/29/2022 | Lake Erie | 17 | at | Findlay | 42 | |||
| Ashland | 20 | at | Hillsdale | 36 | ||||
| Northwood | 3 | at | Tiffin | 48 | ||||
| Kentucky Wesleyan | 10 | at | Walsh | 35 | ||||
| 11/5/2022 | Walsh | 7 | at | Findlay | 20 | |||
| Michigan Tech | 28 | at | Hillsdale | 24 | GLIAC | |||
| Tiffin | 72 | at | Kentucky Wesleyan | 13 | ||||
| Ashland | 31 | at | Lake Erie | 23 | ||||
| Ohio Dominican | 35 | at | Northwood | 24 | ||||
| 11/12/2022 | Kentucky Wesleyan | 10 | at | Ashland | 41 | |||
| Northern Michigan | 33 | at | Lake Erie | 11 | GLIAC | |||
| Walsh | 14 | at | Northwood | 34 | ||||
| Hillsdale | 10 | at | Ohio Dominican | 20 | ||||
| Findlay | 27 | at | Tiffin | 25 | ||||
| 11/19/2022 | Notre Dame OH | 13 | at | Ashland | 20 | D2 Championship Round 1 | MtnE | |
| 11/26/2022 | Ashland | 13 | at | Indiana PA | 19 | D2 Playoffs Round 2 | @ PSAC | |
| 12/3/2022 | Tiffin | 27 | vs | Truman State | 28 | Hobart IN | vs GLV |