| 8/27/2022 | Ave Maria (5-3) | 53 | at | Madonna | 0 | Sun | ||
| 9/3/2022 | Madonna | 0 | at | Marian IN (9-2,9-1) | 86 | |||
| 9/10/2022 | Madonna | 0 | at | Northwood (3-8) | 38 | at GMAC | ||
| 9/17/2022 | Missouri Baptist (4-7,3-6) | 44 | at | Madonna | 37 | OT | ||
| 9/24/2022 | Madonna | 9 | at | Judson (2-8,2-8) | 31 | |||
| 10/1/2022 | Lawrence Tech (3-7,3-6) | 38 | at | Madonna | 10 | |||
| 10/8/2022 | St Francis IN (4-6,4-6) | 53 | at | Madonna | 0 | |||
| 10/15/2022 | Siena Heights (5-5,5-5) | 45 | at | Madonna | 26 | |||
| 10/22/2022 | Madonna | 23 | at | Taylor (5-6,5-5) | 52 | |||
| 11/5/2022 | Concordia MI (5-5,5-4) | 58 | at | Madonna | 13 | |||
| 11/12/2022 | Madonna | 7 | at | Indiana Wesleyan (10-2,9-0) | 79 |
| vs Madonna | vs Other Opponents | Madonna compared to OOs | |
| Record: | 11-0 | 44-59 | |
| Points Scored: | 52.45 | 23.72 | -28.73 |
| Points Allowed: | 11.36 | 27.26 | -15.90 |
| Margin: | 41.09 | -3.54 | -44.63 |
| Total Points: | 63.81 | 50.98 | 12.83 |