| 9/1/2022 | North Greenville | 0 | at | Furman (10-3) | 52 | at SoCon | ||
| 9/10/2022 | Newberry (9-2) | 29 | at | North Greenville | 22 | SAC | ||
| 9/17/2022 | North Greenville | 41 | at | Mississippi College (4-7,3-5) | 19 | |||
| 9/24/2022 | Findlay (7-4) | 27 | at | North Greenville | 34 | GMAC | ||
| 10/1/2022 | North Greenville | 31 | at | West Florida (12-2,8-1) | 34 | |||
| 10/8/2022 | Delta State (11-2,7-2) | 47 | at | North Greenville | 14 | |||
| 10/15/2022 | West Georgia (8-2,6-2) | 38 | at | North Greenville | 35 | |||
| 10/22/2022 | North Greenville | 34 | at | West Alabama (5-6,3-5) | 33 | |||
| 10/29/2022 | Valdosta State (5-6,3-5) | 58 | at | North Greenville | 37 | |||
| 11/5/2022 | North Greenville | 14 | at | Shorter (3-8,1-7) | 31 | |||
| 11/12/2022 | West Georgia (8-2,6-2) | 43 | at | North Greenville | 36 |
| vs North Greenville | vs Other Opponents | North Greenville compared to OOs | |
| Record: | 8-3 | 72-41 | |
| Points Scored: | 37.36 | 33.79 | -3.57 |
| Points Allowed: | 27.09 | 26.19 | 0.90 |
| Margin: | 10.27 | 7.60 | -2.67 |
| Total Points: | 64.45 | 59.98 | 4.47 |