| 9/4/2021 | Florida Atlantic (5-7) | 14 | at | Florida | 35 | CUSA | ||
| 9/11/2021 | Florida | 42 | at | South Florida (2-10) | 20 | at AAC | ||
| 9/18/2021 | Alabama (13-2,8-2) | 31 | at | Florida | 29 | |||
| 9/25/2021 | Tennessee (7-6,4-4) | 14 | at | Florida | 38 | |||
| 10/2/2021 | Florida | 13 | at | Kentucky (10-3,5-3) | 20 | |||
| 10/9/2021 | Vanderbilt (2-10,0-8) | 0 | at | Florida | 42 | |||
| 10/16/2021 | Florida | 42 | at | LSU (6-7,3-5) | 49 | |||
| 10/30/2021 | Georgia (14-1,9-1) | 34 | vs | Florida | 7 | Jacksonville FL | ||
| 11/6/2021 | Florida | 17 | at | South Carolina (7-6,3-5) | 40 | |||
| 11/13/2021 | Samford (4-7) | 52 | at | Florida | 70 | SoCon (1AA) | ||
| 11/20/2021 | Florida | 23 | at | Missouri (6-7,3-5) | 24 | OT | ||
| 11/27/2021 | Florida State (5-7) | 21 | at | Florida | 24 | ACC | ||
| 12/23/2021 | UCF (9-4) | 29 | vs | Florida | 17 | Gasparilla Bowl - Saint Petersburg FL | AAC |
| vs Florida | vs Other Opponents | Florida compared to OOs | |
| Record: | 7-6 | 83-71 | |
| Points Scored: | 26.77 | 30.60 | 3.83 |
| Points Allowed: | 30.69 | 26.23 | 4.46 |
| Margin: | -3.92 | 4.37 | 8.29 |
| Total Points: | 57.46 | 56.83 | 0.63 |