| 9/4/2021 | LSU | 27 | at | UCLA (8-4) | 38 | at P12 | ||
| 9/11/2021 | McNeese State (4-7) | 7 | at | LSU | 34 | SLC (1AA) | ||
| 9/18/2021 | Central Michigan (9-4) | 21 | at | LSU | 49 | MAC | ||
| 9/25/2021 | LSU | 28 | at | Mississippi State (7-6,4-4) | 25 | |||
| 10/2/2021 | Auburn (6-7,3-5) | 24 | at | LSU | 19 | |||
| 10/9/2021 | LSU | 21 | at | Kentucky (10-3,5-3) | 42 | |||
| 10/16/2021 | Florida (6-7,2-6) | 42 | at | LSU | 49 | |||
| 10/23/2021 | LSU | 17 | at | Mississippi (10-3,6-2) | 31 | |||
| 11/6/2021 | LSU | 14 | at | Alabama (13-2,8-2) | 20 | |||
| 11/13/2021 | Arkansas (9-4,4-4) | 16 | at | LSU | 13 | OT | ||
| 11/20/2021 | UL Monroe (4-8) | 14 | at | LSU | 27 | SBC | ||
| 11/27/2021 | Texas A&M (8-4,4-4) | 24 | at | LSU | 27 | |||
| 1/4/2022 | LSU | 20 | vs | Kansas State (8-5) | 42 | Texas Bowl - Houston TX | vs B12 |
| vs LSU | vs Other Opponents | LSU compared to OOs | |
| Record: | 7-6 | 95-58 | |
| Points Scored: | 26.62 | 31.02 | 4.40 |
| Points Allowed: | 26.54 | 23.71 | 2.83 |
| Margin: | 0.08 | 7.31 | 7.23 |
| Total Points: | 53.16 | 54.73 | -1.57 |